The Kansas City Chiefs will look to stay unbeaten when they battle the New Orleans Saints on Monday Night Football. New Orleans has lost two in a row, including a 26-24 decision at Atlanta on Sunday, while Kansas City defeated the Los Angeles Chargers 17-10 in Week 4. The Saints (2-2), tied for second with Atlanta in the NFC South, are 1-1 on the road this season. The Chiefs (4-0), the two-time defending Super Bowl champions, are looking to win their ninth consecutive AFC West crown. The Chiefs will be without leading receiver Rashee Rice, who injured his knee against the Chargers.

Kickoff from GEHA Field at Arrowhead Stadium in Kansas City, Mo., is set for 8:15 p.m. ET. Kansas City is a 5.5-point favorite in the latest Saints vs. Chiefs odds, while the over/under for total points scored is 43.5. Kansas City is a -254 favorite (risk $254 to win $100) on the money line, while New Orleans is a +207 underdog. Before you make any Saints vs. Chiefs bets or predictions, you NEED to see which side SportsLine NFL expert Danny Vithlani is on. 

Vithlani is a New York-based analyst who brings a dynamic approach to his handicapping. He is coming off a 27-15 debut season with SportsLine (plus $1,181 for $100 players, every bet 1 unit). Danny netted 24.8 units in the 2022 NFL season, posting every pick on Instagram. You can find all of Danny's top plays here on SportsLine. He is an OUTSTANDING 22-7 (+1431) on his last 29 NFL picks! Anyone who has followed him is WAY up!

Now, Vithlani has locked in another confident against-the-spread pick for Saints vs. Chiefs.

We can tell you he's leaning Under on the point total, but he knows a crucial X-factor makes one side of the spread a MUST-BACK! You ABSOLUTELY need to see what it is before locking in any picks of your own.

So who wins Saints vs. Chiefs on Monday Night Football, and what x-factor makes one side a must-back? ... Join SportsLine right now to see which side of the Saints vs. Chiefs spread to back, all from the expert who is 22-7 on NFL picks!